Ebola Virus Haemorrhagic Fever 1
Proceedings of an International Colloquium on Ebola Virus Infection and Other Haemorrhagic Fevers held in Antwerp, Belgium, 6-8 December, 1977 2
INTRODUCTION 3
ACKNOWLEDGEMENT 4
PREFACE 5
Table Of Contents 6
CONTENTS (commented) 9
INTRODUCTORY REMARKS 14
SECTION I : EBOLA VIRUS INFECTION 16
1. Clinical Aspects 17
CLINICAL ASPECTS OF EBOLA VIRUS INFECTION IN YAMBUKU AREA, ZAIRE, 1976. 18
CLINICAL ASPECTS OF EBOLA VIRUS DISEASE AT THE NGALIEMA HOSPITAL, KINSHASA, ZAIRE, 1976 23
AFRICAN HAEMORRHAGIC FEVER IN THE SOUTHERN SUDAN, 1976: THE CLINICAL MANIFESTATIONS 28
ISOLATION, MONITORING AND TREATMENT OF A CASE OF EBOLA VIRUS INFECTION 32
2. PATHOLOGY. VIRUS MORPHOLOGY. TAXONOMY. 37
HUMAN PATHOLOGY OF EBOLA (MARIDI) VIRUS INFECTION IN THE SUDAN 38
PATHOLOGY OF EBOLA VIRUS INFECTION 41
EBOLA AND MARBURG VIRUS MORPHOLOGY AND TAXONOMY 54
3. LABORATORY DIAGNOSIS 73
VIROLOGICAL DIAGNOSIS OF EBOLA VIRUS INFECTION 74
SOME OBSERVATIONS ON THE PROPERTIES OF EBOLA VIRUS 77
VIROLOGICAL STUDIES ON A CASE OF EBOLA VIRUS INFECTION IN MAN AND IN MONKEYS 80
4. EPIDEMIOLOGY 86
THE EPIDEMIOLOGY OF EBOLA HAEMORRHAGIC FEVER IN ZAIRE, 1976 87
THE HAEMORRHAGIC FEVER OUTBREAK IN MARIDI, WESTERN EQUATORIA, SOUTHERN SUDAN 100
EBOLA FEVER IN THE SUDAN, 1976 : EPIDEMIOLOGICAL ASPECTS OF THE DISEASE 102
THE NZARA OUTBREAK OF VIRAL HAEMORRHAGIC FEVER 107
VIRAL HAEMORRHAGIC FEVER IN THE SUDAN, 1976 : HUMAN VIROLOGICAL AND SEROLOGICAL STUDIES 110
CONTAINMENT AND SURVEILLANCE OF AN EPIDEMIC OF EBOLA VIRUS INFECTION IN YAMBUKU AREA, ZAIRE, 1976 118
CONTAINMENT AND SURVEILLANCE OF A HOSPITAL OUTBREAK OF EBOLA VIRUS DISEASE IN KINSHASA, ZAIRE, 1976. 124
CONTAINMENT AND SURVEILLANCE OF THE EBOLA VIRUS EPIDEMIC IN SOUTHERN SUDAN 130
COLLECTION OF MAMMALS AND ARTHROPODS DURING THE EPIDEMIC OF HAEMORRHAGIC FEVER IN ZAIRE 133
APPROACHES TOWARDS STUDIES ON POTENTIAL RESERVOIRS OF VIRAL HAEMORRHAGIC FEVER IN SOUTHERN SUDAN (1977) 136
RESULTS OF EBOLA ANTIBODY SURVEYS IN VARIOUS POPULATION GROUPS 142
LOGISTICS IN EPIDEMIOLOGICAL INVESTIGATIONS (ABSTRACT) 145
5. PLASMAPHERESIS PROGRAMS 147
PLASMAPHERESE DANS LE FOYER EPIDEMIQUE DE YAMBUKU, ZAIRE 148
PLASMAPHERESIS MEASURES IN SUDAN 150
EVALUATION OF THE PLASMAPHERESIS PROGRAM IN ZAIRE 151
6. PROBLEMS AND FUTURE NEEDS 155
DISSEMINATED INTRAVASCULAR COAGULATION 156
THE DEVELOPMENT OF A VACCINE AGAINST AFRICAN HEMORRHAGIC FEVER 163
THE EFFECT OF INTERFERON ON EXPERIMENTAL EBOLA VIRUS INFECTION IN RHESUS MONKEYS 168
GROWTH OF LASSA AND EBOLA VIRUSES IN DIFFERENT CELL LINES 173
ATTEMPTS TO CLASSIFY UNGROUPED ARBOVIRUSES BY ELECTRON MICROSCOPY 178
SECTION II OTHER HAEMORRAGIC FEVERS 182
MARBURG VIRUS DISEASE 183
LASSA FEVER : HISTORICAL OVERVIEW AND CONTEMPORARY INVESTIGATION 188
LASSA FEVER VIRUS ANTIBODIES IN MASTOMYS NATALENSIS CAUGHT IN DIFFERENT PARTS OF NIGERIA 192
SOUTH AMERICAN HAEMORRHAGIC FEVERS 196
CRIMEAN - CONGO HEMORRHAGIC FEVER 201
RICKETTSIOSES: CURRENT PROBLEMS OF CLINICAL INTEREST 211
KOREAN HEMORRHAGIC FEVER 217
NEPHROPATHIA EPIDEMICA 225
SECTION III : PUBLIC HEALTH ASPECTS 233
1. SURVEILLANCE IN ENDEMIC COUNTRIES 234
EBOLA HAEMORRHAGIC FEVER : A PUBLIC HEALTH PROBLEM 235
SURVEILLANCE OF HAEMORRHAGIC FEVER IN ENDEMIC AREAS : SUDAN 237
SURVEILLANCE OF HAEMORRHAGIC FEVER IN ENDEMIC AREAS : KENYA 239
THE SURVEILLANCE OF VIRAL HAEMORRHAGIC FEVER IN ZAIRE 240
2. LABORATORY AND FIELD EQUIPMENT 244
LABORATORY AND FIELD SAFETY EQUIPMENT FOR THE MANIPULATION OF HIGHLY INFECTIOUS AGENTS 245
3. HOSPITALISATION 250
HOSPITALISATION OF PATIENTS SUSPECTED OF HIGHLY INFECTIOUS DISEASE 251
THE PLANNING OF A MODERN ISOLATION UNIT IN THE NETHERLANDS 255
4. TRANSPORT AND INTERNATIONAL SURVEILLANCE 257
EBOLA VIRUS DISEASE (EVD) SURVEILLANCE AND MEDICAL EVACUATION OF INTERNATIONAL MEDICAL COMMISSION MEMBERS IN ZAIRE 258
INTERNATIONAL SURVEILLANCE AND TRANSPORT OF EBOLA VIRUS DISEASE AND OTHER HAEMORRHAGIC FEVERS: THE UK EXPERIENCE 265
SURVEILLANCE AND TRANSPORT OF PATIENTS WITH SUSPECT VIRAL HEMORRHAGIC FEVERS THE UNITED STATES EXPERIENCE 268
PARTICIPANTS 275
