Adverse effects after Yellow Fever vaccination



  Yellow Fever Vaccine and Recent Reports of Associated Severe Illness

Recently some cases of a severe viscerotropic adverse event after yellow fever vaccination have been described (see References) who developed severe illness following receipt of yellow fever vaccine (17D-204 or 17DD strains). Although reported in a very small proportion of approximately 300 million worldwide yellow fever vaccine recipients, this association warrants further investigation.

The Robert Koch-Institut (RKI) is enhancing preexisting surveillance for yellow fever vaccine adverse events with special laboratory support.

Medical doctors/clinicians are encouraged to report cases of febrile illness potentially caused by yellow fever vaccination to the RKI by one of the following methods:

 
1.
2.
3.
 Submitting a report by fax to: +49-30-18-754-2625
Filling in the Report Form (WORD 160K) with computer and faxing or mailing it NiedrigM@rki.de
Calling +49-30-18-754-2370 / 2321 (English/German)

  Persons who develop a fever
  • >38.5°C (101.3°F) lasting at least 24 hours and
  • occurring within 30 days of yellow fever vaccination

will be prioritized by RKI for further evaluation.

Note: Because local doctors/clinicians need to be involved in the evaluation, reports cannot be accepted directly from individual patients.

For more information, please see the following:
  
  References

Chan RC, Penney DJ, Little D, et al.
Hepatitis and death following vaccination with 17D-204 yellow fever vaccine.
Lancet 2001;358:121-2.

Martin M, Tsai TF, Cropp B, Chang GJ, et al.
Fever and multisystem organ failure associated with 17D-204 yellow fever vaccination: a report of four cases.
Lancet 2001;358:98-104.

Vasconcelos PF, Luna EJ, Galler R, et al.
Serious adverse events associated with yellow fever 17DD vaccine in Brazil: a report of two cases.
Lancet 2001;358:91-7.

Centers for Disease Control and Prevention:
Notice to readers: Fever, jaundice, and multiple organ system failure associated with 17D-derived yellow fever vaccination, 1996–2001. MMWR 2001;50:343-5.
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